Offline clinical decision-support tool for perioperative fluids and transfusion guidance.
ENKI-CLINICAL Suite · Doctrine v1.0
Decision support only. Does not replace clinical judgment.
How Calculations Work
4-2-1 Maintenance Rule (Doctrine §D1)
Maintenance fluid rate is calculated by weight:
• First 10 kg: 4 mL/kg/hr
• Next 10 kg (11–20 kg): 2 mL/kg/hr
• Each kg above 20: 1 mL/kg/hr
Example: 70 kg adult = 40 + 20 + 50 = 110 mL/hr
Fasting Deficit (Doctrine §D2)
Fasting Deficit (mL) = Maintenance Rate × NPO Hours
Example: 110 mL/hr × 8 hours = 880 mL
50/25/25 Deficit Replacement (Doctrine §D3)
The fasting deficit is replaced over the first 3 hours of surgery:
• Hour 1: 50% of deficit
• Hour 2: 25% of deficit
• Hour 3: 25% of deficit
• Hour 4+: 0 deficit component
Surgical Loss Bands (Doctrine §D4)
Surgical loss rate varies by case classification:
• Minor: 2–4 mL/kg/hr (default 3)
• Moderate: 4–6 mL/kg/hr (default 5)
• Major: 8–10 mL/kg/hr (default 9)
Surgical Loss (mL/hr) = Selected Rate × Weight (kg)
Transfusion Thresholds (Doctrine §F1–F2)
Adult RBC triggers:
• Stable, non-bleeding: Hb < 7 g/dL
• Active hemorrhage/shock: Hb < 8 or symptomatic
• IHD/ACS: Hb < 9 g/dL
• Neurocritical: target 8–9 range
• Pregnancy/PPH: Hb < 7; unstable ≥8
Pediatric (≥1 month):
• Stable Hb < 7: PRBC 10–15 mL/kg
• Active bleed Hb < 8: PRBC 15 mL/kg + FFP 10–15 mL/kg
• Cardiac Hb < 9: PRBC 10–15 mL/kg
Pediatric mL/kg Dosing (Doctrine §F2–F5)
All pediatric blood product dosing is weight-based:
• PRBC: 10–15 mL/kg
• FFP: 10–15 mL/kg
• Cryoprecipitate: 1 unit per 10 kg
• Platelets: dose per local protocol (not specified in doctrine)
Massive Hemorrhage Protocol Cycles (Doctrine §G2)
If Whole Blood available (Cycle A):
1 WB → 1 FFP → 1 WB → 1 FFP (repeat)
If PRBC + FFP only (Cycle B):
PRBC:FFP = 1:1 until bleeding slows; add cryo early if available
Pediatric MHP:
PRBC 10–15 mL/kg alternating with FFP 10–15 mL/kg
Early cryo: 1 unit per 10 kg
OB emphasis: Fibrinogen falls early → cryo upfront if available